Modeling Parkinson’s disease pathology in human dopaminergic neurons by sequential exposure to α-synuclein fibrils and proinflammatory cytokines

2024/10/08 by Armin Bayati, Riham Ayoubi, Adriana Aguila +28 · 1 voice
Medicine · Neuroscience · #Nerve injury and regeneration #Nuclear Receptors and Signaling #Parkinson's Disease Mechanisms and Treatments

paper · doi:10.1038/s41593-024-01775-4

crossref issued 2024/10/08 · crossref published 2024/10/08 · crossref published-online 2024/10/08 · openalex publication_date 2024/10/08 · crossref created 2024/10/08 · crossref published-print 2024/12/01 · openalex created_date 2025/10/10 · crossref deposited 2026/03/12 · openalex updated_date 2026/07/23 · crossref indexed 2026/07/25

Citations

• α-Synuclein in Lewy bodies
• Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy
• Dopamine-modified α-synuclein blocks chaperone-mediated autophagy
• PHASE AND ELECTRON MICROSCOPIC OBSERVATIONS OF LEWY BODIES AND MELANIN GRANULES IN THE SUBSTANTIA NIGRA AND LOCUS CAERULEUS IN PARKINSONʼS DISEASE
• Staging of brain pathology related to sporadic Parkinson’s disease
• Role of LAMP-2 in Lysosome Biogenesis and Autophagy

Discussions

• And a last paper I liked this week: iPSC DA neurons form Lewy body-like inclusions after treatment with α-synuclein preformed fibrils (PFFs), but only when combined with an immune challenge model (int [bsky, 0 points, 0 comments]