2024/01/11 by J. Pinto Cohen, Hugues Petitjean, M. Belen Blasco +1 · 1 voice
Medicine · Pharmacology, Toxicology and Pharmaceutics · #Cannabis and Cannabinoid Research #Forensic Toxicology and Drug Analysis #Substance Abuse Treatment and Outcomes
paper · pdf · doi:10.1017/neu.2023.60
openalex publication_date 2024/01/11 · openalex created_date 2025/10/10 · openalex updated_date 2026/05/21
OBJECTIVES: The link between cannabis use and psychotic symptoms or disorders is well known. However, the relation between cannabis withdrawal and psychotic symptoms is less studied. METHODS: To our knowledge, this is the first publication of an observational systematic report of cannabis-induced psychotic disorder with onset during withdrawal. Here, we review patients presenting to a major emergency room in Montreal between January 2020 and September 2023 in a context of psychotic symptoms following cannabis cessation. RESULTS: In total, seven male and one female patients presented at the peak of cannabis withdrawal with acute psychotic symptoms, representing less than 1% of all emergency service admissions. CONCLUSIONS: We discuss current knowledge regarding the endocannabinoid system and dopamine homeostasis to formulate hypotheses regarding these observations.