Topical siRNA therapy of diabetic-like wound healing

2024/11/22 by Eva Neuhöferová, Marek Kindermann, Matěj Buzgo +4 · 1 voice
Medicine · Materials Science · #Wound Healing and Treatments #Electrospun Nanofibers in Biomedical Applications #Corneal Surgery and Treatments

paper · doi:10.1039/d4tb01547a

openalex publication_date 2024/11/22 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04

Abstract

toxicity, biological efficacy, and handling. The treatment results in significant local inhibition of MMP-9 and a shortening of the wound healing time. The scar formation in treated diabetic-like mice becomes comparable with that in non-treated diabetes-free mice. Our results suggest that the application of our biocompatible dressing loaded with a non-toxic vector nanosystem is an effective and promising approach to gene therapy of non-healing wounds.

Discussions

• #research #woundhealing #siRNA Topical siRNA therapy of diabetic-like wound healing (Cígler, Benson) - JMaterChem B: doi.org/10.1039/D4TB... @iocbprague.bsky.social #TULiberec #CharlesUniversity #UC [bsky, 0 points, 1 comments]

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