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Serotonin, Predictive Processing and Psychedelics

2022/04/19 by Matteo Colombo · 1 voice
Psychology · #Psychedelics and Drug Studies

paper · pdf · doi:10.33735/phimisci.2022.9320

openalex publication_date 2022/04/19 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Letheby’s "Philosophy of Psychedelics" relies on Predictive Processing to try and find unifying explanations relevant to understanding how serotonergic psychedelics work in psychiatric therapy, what subjective experiences are associated with their use and whether such experiences are epistemically defective. But if Predictive Processing lacks genuinely explanatory unifying power, Letheby’s account of psychedelic therapy risks being unwarranted. In this commentary, I motivate this worry and sketch an alternative interpretation of psychedelic therapy within the Reinforcement Learning framework.

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