2024/12/20 by Roy Meys, Frits M.E. Franssen, Alex J. van ‘t Hul +26 · 1 voice
Medicine · Social Sciences · #Asthma and respiratory diseases #Delphi Technique in Research #Chronic Obstructive Pulmonary Disease (COPD) Research
paper · pdf · doi:10.1186/s12955-024-02321-3
openalex publication_date 2024/12/20 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/03
RATIONALE: Knowledge about the clinical importance of patient-reported outcome measures (PROMs) in severe asthma is limited. OBJECTIVES: To assess whether and to what extent asthma exacerbations affect changes in PROMS over time and asthma-specific PROMs can predict exacerbations in adult patients with severe asthma in usual care. METHODS: 67.5 ± 21.3%pred) from the U-BIOPRED cohort were analyzed. The included PROMs were: Asthma Control Questionnaire (ACQ5); Asthma Quality of Life Questionnaire (AQLQ); Hospital Anxiety and Depression scale (HADS); Epworth Sleepiness Scale (ESS); Medication Adherence Report Scale (MARS); Sino-Nasal Outcomes Test (SNOT20). Participants were assessed at baseline and after 12-18 months of usual care. RESULTS: , FeNO and eosinophilic cell count. Patients presenting no exacerbations during follow-up showed a statistically significant improvement in all PROMs (except for MARS), whereas individuals experiencing > 2 exacerbations showed a deterioration. Baseline ACQ5 was a predictor of exacerbations with an AUC of 0.590 (95%CI 0.514-0.666). CONCLUSIONS: The association of PROMs with clinical measures was poor in severe asthmatics. Moreover, PROMs were prone to changes in usual care, with exacerbations playing a key role. PROMs need to be systematically evaluated in severe asthma to improve clinical care based on specific patient's needs.