Order by chance: origins and benefits of stochasticity in immune cell fate control

2019/11/15 by Kathleen Abadie, Nicholas A. Pease, Matthew J. Wither +1 · 1 voice
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #Immune Cell Function and Interaction #Single-cell and spatial transcriptomics #T-cell and B-cell Immunology

paper · doi:10.1016/j.coisb.2019.10.013

openalex publication_date 2019/11/15 · crossref created 2019/11/15 · crossref issued 2019/12/01 · crossref published 2019/12/01 · crossref published-print 2019/12/01 · openalex created_date 2025/10/10 · crossref deposited 2025/11/11 · crossref indexed 2026/01/15 · openalex updated_date 2026/08/01

Citations

• Intrinsic transcriptional heterogeneity in B cells controls early class switching to IgE
• Endogenous Nur77 Is a Specific Indicator of Antigen Receptor Signaling in Human T and B Cells

Discussions

• We are curious how progenitors can give rise to multiple cell types in defined numbers and proportions. Unlike some embryos, blood progenitors often have to generate multiple cell types in the absenc [bsky, 0 points, 1 comments]