The carbonyl nucleobase adduct M3Ade is a potent antigen for adaptive polyclonal MR1-restricted T cells

2024/12/18 by Andrew Chancellor, Daniel Constantin, Giuliano Berloffa +20 · 1 voice
Immunology and Microbiology · Biochemistry, Genetics and Molecular Biology · #Immune Cell Function and Interaction #Immunotherapy and Immune Responses #Adenosine and Purinergic Signaling

paper · doi:10.1016/j.immuni.2024.11.019

openalex publication_date 2024/12/18 · openalex created_date 2024/12/19 · openalex updated_date 2026/08/04

Abstract

Ade is an MR1-presented self-metabolite that enables stimulation and tracking of human-MR1T cells from blood and tissue, aiding our understanding of their roles in health and disease.

Citations

• ggplot2: Elegant Graphics for Data Analysis
• Hallmarks of Cancer: The Next Generation
• The Immunology of CD1- and MR1-Restricted T Cells
• Phasercrystallographic software
• UMAP: Uniform Manifold Approximation and Projection for Dimension Reduction
• Integrated analysis of multimodal single-cell data
• Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation

Discussions

• 🚩 The little things that MAITter (sorry matter) - a 2-4 atom adduct on adenine is a metabolite presented on MR1 to MAIT cells doi.org/10.1016/j.im... [bsky, 0 points, 0 comments]