Mechanical Tension Promotes Formation of Gastrulation-like Nodes and Patterns Mesoderm Specification in Human Embryonic Stem Cells

2020/11/17 by Jonathon M. Muncie, Nadia M.E. Ayad, Johnathon N. Lakins +3 · 1 voice · 3 citations
Biochemistry, Genetics and Molecular Biology · Engineering · #3D Printing in Biomedical Research #Cellular Mechanics and Interactions #Pluripotent Stem Cells Research

paper · doi:10.1016/j.devcel.2020.10.015

openalex publication_date 2020/11/17 · crossref created 2020/11/17 · crossref issued 2020/12/01 · crossref published 2020/12/01 · crossref published-print 2020/12/01 · openalex created_date 2025/10/10 · crossref deposited 2026/05/12 · crossref indexed 2026/07/14 · openalex updated_date 2026/08/01

Citations

• Local cell interactions and self-amplifying individual cell ingression drive amniote gastrulation
• Interfacial geometry dictates cancer cell tumorigenicity
• Third-generation in situ hybridization chain reaction: multiplexed, quantitative, sensitive, versatile, robust

Cited by

• Mechanical induction in metazoan development and evolution: from earliest multi-cellular organisms to modern animal embryos
• Neuroepithelial organoid patterning is mediated by a neighborhood watch mechanism
• Cell Shape and Forces in Elastic and Structured Environments: From Single Cells to Organoids

Discussions

• Paper 1: @jmmuncie and colleagues from Valerie A. Weaver lab found that tissue tension prior to differentiation regulates mesoderm specification in micropatterned colonies https://doi.org/10.1016/j.de [bsky, 0 points, 1 comments]