Spike mutation D614G alters SARS-CoV-2 fitness

2020/10/26 by Jessica A. Plante, Yang Liu, Jianying Liu +20 · 1 voice · 11 citations
Medicine · #COVID-19 Clinical Research Studies #SARS-CoV-2 and COVID-19 Research #SARS-CoV-2 detection and testing

paper · pdf · doi:10.1038/s41586-020-2895-3

crossref issued 2020/10/26 · crossref published 2020/10/26 · crossref published-online 2020/10/26 · openalex publication_date 2020/10/26 · crossref created 2020/10/26 · crossref published-print 2021/04/01 · crossref deposited 2024/08/16 · openalex created_date 2025/10/10 · crossref indexed 2026/07/23 · openalex updated_date 2026/08/01

Citations

• A pneumonia outbreak associated with a new coronavirus of probable bat origin
• SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
• Virological assessment of hospitalized patients with COVID-2019
• Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus
• An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

Cited by

• The SARS-CoV-2 spike protein is vulnerable to moderate electric fields
• Substitution-Mutation Rate Ratio (c/µ) As Molecular Adaptation Test Beyond Ka/Ks: A SARS-COV-2 Case Study
• Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift
• N440K variant of SARS-CoV-2 has Higher Infectious Fitness
• Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies
• The biological and clinical significance of emerging SARS-CoV-2 variants
• Mutation Signatures and In Silico Docking of Novel SARS-CoV-2 Variants of Concern
• Large-scale analysis of SARS-CoV-2 spike-glycoprotein mutants demonstrates the need for continuous screening of virus isolates
• Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity
• The SARS-CoV-2 Lambda variant exhibits enhanced infectivity and immune resistance
• Genetic Characteristics and Phylogeny of 969-bp S Gene Sequence of SARS-CoV-2 from Hawaii Reveals the Worldwide Emerging P681H Mutation

Discussions

• SARS-CoV2 was not perfectly adapted to humans from the get-go. Rapid replacement of the original Wuhan strain by the D614G variant shows that the virus still needed to adapt to its new host. D614G als [bsky, 0 points, 2 comments]