2025/02/06 by Takashi Akagi, Naoko Fujita, Kenta Shirasawa +13 · 1 voice · 1 citation
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · #Chromosomal and Genetic Variations #Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities #Plant Reproductive Biology
paper · doi:10.1126/science.adk9074
openalex publication_date 2025/02/06 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/23
, in which giant heteromorphic sex chromosomes were first discovered in 1923. It has long been known that the Y chromosome consists mainly of a male-specific region that does not recombine with the X chromosome and carries the sex-determining genes and genes with other male functions. However, only with a whole Y chromosome assembly can candidate genes be validated experimentally and their locations determined and related to the suppression of recombination. We describe the genomic changes as the ancestral chromosome evolved into the current XY pair, testing ideas about the evolution of large nonrecombining regions and the mechanisms that created the present recombination pattern.