2014/11/01 by Michelle Dias Santos Santiago, Deusvenir de Souza Carvalho, Alberto Alain Gabbai +5 · 1 citation
Medicine · Neuroscience · #Circadian rhythm and melatonin #Migraine and Headache Studies #Traumatic Brain Injury Research
paper · pdf · doi:10.1590/0004-282x20140148
crossref issued 2014/11/01 · crossref published 2014/11/01 · crossref published-print 2014/11/01 · openalex publication_date 2014/11/01 · crossref created 2014/11/15 · crossref deposited 2017/05/27 · openalex created_date 2025/10/10 · crossref indexed 2026/07/30 · openalex updated_date 2026/07/31
UNLABELLED: To compare the preventive treatment benefits of amitriptyline and aerobic exercise or amitriptyline alone in patients with chronic migraine. METHOD: Sixty patients, both genders, aged between 18 and 50 years, with a diagnosis of chronic migraine, were randomized in groups called amitriptyline and aerobic exercise or amitriptyline alone. The following parameters were evaluated: headache frequency, intensity and duration of headache, days of the analgesic medication use, body mass index (BMI), Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) scores. RESULTS: In the evaluated parameters, was observed decrease in headache frequency (p=0.001), moderate intensity (p=0.048), in headache duration (p=0.001), the body mass index (p=0.001), Beck Depression Inventory (p=0.001) and Beck Anxiety Inventory scores (p=0.001), when groups were compared in the end of third month. CONCLUSION: In this study, the amitriptyline was an effective treatment for chronic migraine, but its efficacy was increased when combined with aerobic exercise.