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Towards electrospray-assisted production of lipid-based synthetic cell assemblies

2025/01/01 by P. Vink, Lawrence W. Honaker, Siddharth Deshpande · 1 voice
Biochemistry, Genetics and Molecular Biology · Chemistry · Engineering · #Electrohydrodynamics and Fluid Dynamics #Lipid Membrane Structure and Behavior #Mass Spectrometry Techniques and Applications

paper · pdf · doi:10.1039/d4sm01284d

openalex publication_date 2025/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

interfacial lipid assembly. Interestingly, the formed vesicles exhibit a nebulous and disordered, but highly stable coating of lipids, and tend to form interconnected vesicle populations. Remarkably, the lipid assemblies can continue to rearrange and reconfigure over time, leading to spherical vesicles with ultra-thin and smooth lipid coating, suggestive of liposomes. Our work provides a new avenue, in the form of electrospray, to form various lipid-based assemblies using all-aqueous systems and we believe this platform can be further exploited for high-throughput vesicle production and higher-order assemblies.

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