2025/02/27 by Andrey Lavrov, Nikolai P. Melnikov, Fyodor V. Bolshakov +5 · 1 voice
Biochemistry, Genetics and Molecular Biology · Engineering · Environmental Science · #Marine Biology and Environmental Chemistry #Marine Ecology and Invasive Species #Planarian Biology and Electrostimulation
paper · pdf · doi:10.1002/1873-3468.70025
openalex publication_date 2025/02/27 · openalex created_date 2025/02/28 · openalex updated_date 2026/08/01
Sponges (phylum Porifera) are early-branching metazoans demonstrating an outstanding example of whole-body regeneration, cell reaggregation. During the process, single cells form aggregates capable of progressive development and reconstruction of intact sponges. This study provides the first comprehensive analysis of cell proliferation and cell death during cell reaggregation in a marine demosponge, Halisarca dujardinii. Relatively high proliferative activity occurs at the early and late stages of the reaggregation. This proliferation seems to be a consequence of intact tissue turnover rather than a prerequisite for aggregate development. The contribution of cell death is limited to a short period during the aggregate epithelization. Cell reaggregation in demosponges appears to be a morphallactic restorative process relying primarily on cell migration, dedifferentiation, and transdifferentiation.