Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane

2021/03/18 by Masahiro Maruoka, Panpan Zhang, Hiromi Mori +5 · 1 voice · 5 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #Cell death mechanisms and regulation #Phagocytosis and Immune Regulation #RNA Interference and Gene Delivery

paper · pdf · doi:10.1016/j.molcel.2021.02.025

openalex publication_date 2021/03/18 · crossref created 2021/03/18 · crossref issued 2021/04/01 · crossref published 2021/04/01 · crossref published-print 2021/04/01 · openalex created_date 2025/10/10 · crossref deposited 2025/10/22 · crossref indexed 2026/07/23 · openalex updated_date 2026/07/29

Cited by

• Phospholipid scrambling induced by an ion channel/metabolite transporter complex
• In vivo CRISPR screening directly targeting testicular cells
• Extracellular calcium functions as a molecular glue for transmembrane helices to activate the scramblase Xkr4
• Genome-Wide Screening Approaches for Biochemical Reactions Independent of Cell Growth
• Protocol for in vivo CRISPR screening targeting murine testicular cells

Discussions

• What is revival screening? In this Molecular Cell paper, Dr. Maruoka illustrates how he was able to use this method to screen for sgRNAs enriched in dying cells 😵 Interested? Read more here: doi.org [bsky, 0 points, 0 comments]