Enantioselective modular synthesis of α-aryl-α-heteroaryl aminonitriles with parts per million organocatalyst loading: mechanistic investigation for stereochemical origins

2025/01/01 by Yusuke Oyamada, Kaito Ishikawa, Tsunayoshi Takehara +2 · 1 voice
Biochemistry, Genetics and Molecular Biology · Chemistry · #Asymmetric Synthesis and Catalysis #Chemical Synthesis and Analysis #Radical Photochemical Reactions

paper · doi:10.1039/d4qo02362e

openalex publication_date 2025/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/05/21

Abstract

An enantioselective Friedel-Crafts reaction of iminonitriles gave chiral α-aryl-α-heteroarylaminonitriles in high yield with good enantioselectivity. Pyrrole and indole additions produced different stereochemistries under the same chiral catalyst, explained by DFT.

Citations

• Prescribed drugs containing nitrogen heterocycles: an overview
• Catalytic Enantioselective Construction of an α-Thio-Substituted α-Aminonitriles-Bearing Tetrasubstituted Carbon Center

Discussions

• 👉Research article by Shuichi Nakamura et al Enantioselective modular synthesis of α-aryl-α-heteroaryl aminonitriles with parts per million #organocatalyst loading: mechanistic investigation for ster [bsky, 0 points, 0 comments]

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