2023/08/14 by Nianchao Qian, Joshua A. Weinstein · 1 voice · 6 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Advanced Fluorescence Microscopy Techniques #Artificial intelligence #Biology #Cell Image Analysis Techniques #Computational biology #Computer science #DNA #Evolutionary biology #Gene #Genetics #Modality (human–computer interaction) #Neuroscience #Organism #Single-cell and spatial transcriptomics #Zebrafish
paper · pdf · doi:10.1101/2023.08.11.553025
published in bioRxiv (Cold Spring Harbor Laboratory) (Cold Spring Harbor Laboratory)
openalex publication_date 2023/08/14 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Lymphatic, nervous, and tumoral tissues, among others, exhibit physiology that emerges from three-dimensional interactions between genetically unique cells. A technology capable of volumetrically imaging transcriptomes, genotypes, and morphologies in a single de novo measurement would therefore provide a critical view into the biological complexity of living systems. Here we achieve this by extending DNA microscopy, an imaging modality that encodes a spatio-genetic map of a specimen via a massive distributed network of DNA molecules inside it, to three dimensions and multiple length scales in developing zebrafish embryos.