The complex interplay between aging and cancer

2025/03/04 by Lucrezia A. Trastus, Fabrizio d’Adda di Fagagna · 1 voice
Biochemistry, Genetics and Molecular Biology · Medicine · #FOXO transcription factor regulation #Genetics, Aging, and Longevity in Model Organisms #Telomeres, Telomerase, and Senescence

paper · doi:10.1038/s43587-025-00827-z

crossref issued 2025/03/04 · crossref published 2025/03/04 · crossref published-online 2025/03/04 · openalex publication_date 2025/03/04 · crossref created 2025/03/04 · crossref deposited 2025/03/19 · openalex created_date 2025/10/10 · crossref indexed 2026/07/27 · openalex updated_date 2026/08/03

Citations

• The serial cultivation of human diploid cell strains
• Does age matter? The impact of rodent age on study outcomes
• Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
• Pan-cancer analysis of whole genomes
• An aged immune system drives senescence and ageing of solid organs
• Hallmarks of Cancer: New Dimensions
• The importance of aging in cancer research
• Hallmarks of aging: An expanding universe
• Loss of epigenetic information as a cause of mammalian aging
• Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Discussions

• Important review in Nature Aging on the mechanistic links between aging and cancer, covering DNA damage, telomere biology, and immunosenescence. Relevant for both basic and translational research. Hav [bsky, 0 points, 0 comments]