2025/04/01 by Hannah Thomson, Izelle Labuschagne, Arush Honnedevasthana Arun +12 · 1 voice
Neuroscience · #EEG and Brain-Computer Interfaces #Functional Brain Connectivity Studies #Neural and Behavioral Psychology Studies
paper · doi:10.1101/2025.03.31.25324487
openalex publication_date 2025/04/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/14
ABSTRACT Cannabis use disorder (CUD) affects ∼22M people globally and is characterised by difficulties in cutting down and quitting use, but the underlying neurobiology remains unclear. We examined resting-state functional connectivity (rsFC) between regions-of-interest (ROIs) of the addiction neurocircuitry and the rest of the brain in 65 individuals with moderate-to-severe CUD who reported attempts to cut down or quit, compared to 42 controls, and explored the association between rsFC and cannabis exposure and related problems, to elucidate potential drivers of rsFC alterations. The CUD group showed greater rsFC than controls between ROIs implicated in reward processing and habitual substance use (i.e., nucleus accumbens, putamen, pallidum) and occipito/parietal areas implicated in salience processing and disinhibition. Putamen-occipital rsFC correlated with levels of problematic cannabis use and depression symptoms. CUD appears to show neuroadaptations of the addiction neurocircuitry, previously demonstrated in other substance use disorders.