2025/02/04 by Antoine Chatrenet, Pierre‐Yves de Müllenheim, Massimo Torreggiani +4 · 1 voice · 4 citations
Medicine · #Cardiovascular and exercise physiology #Dialysis and Renal Disease Management #Disease #Endocrinology #Internal medicine #Kidney disease #Medicine #Muscle mass #Muscle strength #Nutrition and Health in Aging #Observational study #Physical medicine and rehabilitation #Physical therapy #Physiology #Sarcopenia #Skeletal muscle
paper · pdf · doi:10.1093/ckj/sfaf036
published in Clinical Kidney Journal 18(3), sfaf036 (Oxford University Press)
openalex publication_date 2025/02/04 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Background: Chronic kidney disease (CKD) is commonly associated with multifactorial neuromuscular impairments. Few studies have investigated CKD-induced changes in maximal voluntary force (MVF), and even fewer have longitudinal follow-up. The aim of this study is to investigate whether CKD progression modifies the relationship between skeletal muscle mass and force, and the prevalence of sarcopaenia and sarcopenic obesity. Methods: The data used were prospectively collected during routine check-ups in a network of nutritional centres in Mexico and retrospectively analysed. From a dataset of 5430 patients, we selected 1098 patients with available anthropometric, kidney function, handgrip and bioimpedance data. The relationship between appendicular skeletal muscle mass (ASM) and MVF was investigated using mixed models and adjusted for age, sex, body mass index, physical activity level and CKD aetiology. Sarcopaenia prevalence were tested across period of follow-up using the Cochran-Mantel-Haenzen for repeated measures and across CKD stages using the Chi-2 test. Results: < .001, respectively]. The prevalence of sarcopaenia and sarcopaenic obesity did not differ across CKD stages, but recovery was most commonly observed in CKD G1-G2. Slope analysis showed an independent interaction between the slopes of kidney function and ASM on MVF evolution over time. Conclusions: CKD negatively, progressively and independently affects the neuromuscular system, and force production is reduced for any given muscle mass as CKD progresses. While no association was found between CKD stage and prevalence of sarcopaenia, recovery was more frequent in the early CKD stages. These results suggest the importance of early rehabilitation programs to improve musculoskeletal health, quality of life and survival in CKD patients.