Accelerated biological ageing in familial pulmonary fibrosis

2025/03/20 by Ana Pm Serezani, Daphne B. Mitchell, Joy D. Cogan +7 · 1 voice
Medicine · #Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis #Pulmonary Hypertension Research and Treatments

paper · doi:10.1183/13993003.02427-2024

openalex publication_date 2025/03/20 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

<title>Extract</title> Short telomere length in peripheral blood cells and lung epithelial cells are common features of familial pulmonary fibrosis (FPF) and sporadic idiopathic pulmonary fibrosis (IPF) [1]. Telomere length decreases during normal ageing, and we recently reported that asymptomatic first-degree relatives of patients with FPF (termed “at-risk relatives”) have shorter telomeres at enrolment and a faster annual decline in telomere length than expected [2].

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