Fibroblast activation protein-targeted chimeric antigen-receptor-modified NK cells alleviate cardiac fibrosis

2025/05/03 by Qi Zheng, Hao Li, Yongliang Jiang +6 · 1 voice
Medicine · #Cardiac Fibrosis and Remodeling #Cardiac Structural Anomalies and Repair #Peptidase Inhibition and Analysis

paper · doi:10.1016/j.intimp.2025.114760

openalex publication_date 2025/05/03 · crossref created 2025/05/03 · crossref issued 2025/06/01 · crossref published 2025/06/01 · crossref published-print 2025/06/01 · openalex created_date 2025/10/10 · crossref deposited 2025/11/07 · crossref indexed 2026/05/06 · openalex updated_date 2026/07/23

Citations

• NK cell-based cancer immunotherapy: from basic biology to clinical development
• Necroptosis, pyroptosis and apoptosis: an intricate game of cell death
• Targeting fibroblast phenotype switching in cardiac remodelling as a promising antifibrotic strategy

Discussions

• Fibroblast activation protein-targeted CAR-NK-92 cells can specifically recognize FAP+ target cells and exert potent anti-fibrotic effects both in vitro and in vivo doi.org/10.1016/j.in... [bsky, 0 points, 0 comments]