2024/01/01 by Ning Jiang, Wanqing Ding, Xiaojuan Zhu +6 · 1 voice
Biochemistry, Genetics and Molecular Biology · Engineering · Medicine · #Cancer Research and Treatments #Cancer, Stress, Anesthesia, and Immune Response #Nanoplatforms for cancer theranostics
paper · doi:10.34133/bdr.0038
openalex publication_date 2024/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Nissle 1917 (ECN) through electrostatic absorption (C@ECN) to suppress ECN-induced COX-2 up-regulation and enhance the synergistic antitumor effect of doxorubicin (DOX). C@ECN improved the antitumor effect of DOX by restraining COX-2 expression. In addition, local T lymphocyte infiltration was induced by the ECN to enhance immunotherapy efficacy in the tumor microenvironment. Considering the biosafety of C@ECN, a hypoxia-induced lysis circuit, pGEX-Pvhb-Lysis, was introduced into the ECN to limit the number of ECNs in vivo. Our results indicate that this system has the potential to enhance the synergistic effect of ECN with chemical drugs to inhibit tumor progression in medical oncology.