2025/05/19 by Yan Xu, Peining Niu, Tao Liu +6 · 1 voice
Medicine · Psychology · #Psychopathy, Forensic Psychiatry, Sexual Offending #Sexual function and dysfunction studies #Sexuality, Behavior, and Technology
paper · pdf · doi:10.1111/andr.70064
openalex publication_date 2025/05/19 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/23
INTRODUCTION: Sexual desire has been found to be associated with brain areas involved in sexual excitation and inhibition. However, little is known regarding whether hypoactive sexual desire disorder patients have structural abnormalities related to hypofunctional excitation or hyperfunctional inhibition in the brain. METHODS: Magnetic resonance imaging data were collected from 26 hypoactive sexual desire disorder patients and 28 healthy controls. The structural brain networks were constructed based on diffusion tensor imaging data. Finally, the nodal parameters were calculated by the graph theoretical analysis and were compared between hypoactive sexual desire disorder and healthy controls. RESULTS: There were no significant differences in the age, education level, and scores of emotional scales between groups. Meanwhile, all hypoactive sexual desire disorder patients showed normal hormone levels. Compared with healthy controls, hypoactive sexual desire disorder patients showed higher scores on the Arizona Sexual Experience Scale and its sexual desire subscale. In fractional anisotropy-weighted brain networks, a decreased clustering coefficient was found in the left middle frontal gyrus (orbital part), and decreased local efficiency was found in the left amygdala of hypoactive sexual desire disorder patients when compared with healthy controls. CONCLUSION: The present study demonstrated impaired left middle orbital frontal gyrus and amygdala in the structural brain network of hypoactive sexual desire disorder patients, which might be the central pathological mechanisms underlying hypoactive sexual desire disorder and could be used as a neuroimaging diagnostic biomarker for hypoactive sexual desire disorder.