Placental growth factor enhances inflammatory toll-like receptor responses in syncytiotrophoblasts

2025/05/24 by Laura F. Newell, Shernan G. Holtan, Leena Kadam +2 · 1 voice
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Angiogenesis and VEGF in Cancer #Pregnancy and preeclampsia studies #Reproductive System and Pregnancy

paper · doi:10.1016/j.placenta.2025.05.023

openalex publication_date 2025/05/24 · crossref created 2025/05/24 · crossref issued 2025/08/01 · crossref published 2025/08/01 · crossref published-print 2025/08/01 · openalex created_date 2025/10/10 · crossref deposited 2026/05/13 · crossref indexed 2026/07/18 · openalex updated_date 2026/08/01

Citations

• Cutting Edge: Distinct Regulatory Mechanisms Control Proinflammatory Cytokines IL-18 and IL-1β
• Overview of the IL‐1 family in innate inflammation and acquired immunity

Discussions

• What started with a curious finding—elevated placental growth factor (PlGF) in patients with graft-versus-host disease (#GVHD)—led to this collaboration showing that PlGF ramps up inflammation in plac [bsky, 0 points, 0 comments]