1990/01/01 by Tarja Ruuska, Timo Vesikari · 2 citations
Medicine · #Hepatitis Viruses Studies and Epidemiology #Respiratory viral infections research #Viral gastroenteritis research and epidemiology
paper · doi:10.3109/00365549009027046
crossref issued 1990/01/01 · crossref published 1990/01/01 · crossref published-print 1990/01/01 · openalex publication_date 1990/01/01 · crossref created 2007/11/20 · crossref published-online 2009/07/08 · crossref deposited 2020/04/28 · openalex created_date 2025/10/10 · crossref indexed 2026/07/29 · openalex updated_date 2026/07/30
65 episodes of rotavirus diarrhoea, detected during a longitudinal follow-up of 336 infants from birth to 24-32 months of age, were analyzed for clinical symptoms. Rotavirus gastroenteritis was characterized by watery diarrhoea, vomiting (particularly in older children), fever and dehydration. A 0-20 point numerical score was devised according to the distribution of clinical features in the patients. Using this system, the mean severity score for the 65 episodes of rotavirus diarrhoea was 11.0 +/- 3.7 as compared to 5.6 +/- 3.2 for the 183 episodes of non-rotavirus diarrhoea in the same population (p less than 0.0001, t-test). The 20 point score is proposed for analysis of efficacy studies of candidate rotavirus vaccines.