2014/12/22 by A V Galenko, Alexey V. Galenko, A F Khlebnikov +7
Biochemistry, Genetics and Molecular Biology · Chemistry · #Chemical Synthesis and Analysis #Click Chemistry and Applications #Synthesis and Catalytic Reactions
paper · doi:10.1070/rcr4503
openalex publication_date 2014/12/22 · crossref created 2014/12/22 · crossref issued 2015/04/30 · crossref published 2015/04/30 · crossref published-print 2015/04/30 · crossref published-online 2015/05/06 · crossref deposited 2024/06/06 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29 · crossref indexed 2026/07/29
The preparation methods and reactions of isoxazoles are described and systematized on the basis of analysis of the literature published from 2005 to present. In the discussion of synthesis, major attention is focused on the most efficient approaches: condensation of hydroxylamine with 1,3-dielectrophiles and reactions of nitrile oxides with alkenes and alkynes. Five-membered ring opening reactions leading to acyclic functionalized or other heterocyclic compounds are considered. The transformations of isoxazole derivatives that occur without ring cleavage to form fused heterocyclic systems, as well as reactions that lead to the introduction of C-substituents into isoxazoles, are considered. Data on the biological activity of some isoxazole derivatives are reported. The bibliography includes 439 references.