2009/12/01 by Pedro Weslley Rosário, Pedro Weslley Rosario, Daniela Santos Salles +2
Medicine · #Multiple and Secondary Primary Cancers #Thyroid Cancer Diagnosis and Treatment #Thyroid and Parathyroid Surgery
paper · pdf · doi:10.1590/s0004-27302009000900011
crossref issued 2009/12/01 · crossref published 2009/12/01 · crossref published-print 2009/12/01 · openalex publication_date 2009/12/01 · crossref created 2010/01/28 · openalex created_date 2016/06/24 · crossref deposited 2024/03/23 · crossref indexed 2026/07/30 · openalex updated_date 2026/07/31
OBJECTIVE: To report the results of cytology and histology obtained for a series of systematically resected thyroid nodules >or= 4 cm. METHODS: A group of 151 patients with thyroid nodules >or= 4 cm was submitted to surgery despite the cytology result. RESULTS: Malignancy was confirmed histologically in 22.5% of the patients. Excluding cases of insufficient material, cytology was benign in only 3/31 carcinomas (90.3% sensitivity). The frequency of malignancy was 35% among nodules with indeterminate cytology (follicular neoplasm), and there was a predominance (77%) of papillary carcinoma. The negative predictive value of benign cytology was 96.4%. CONCLUSIONS: The false-negative rate of cytology in thyroid nodules >or= 4 cm does not justify systematic resection of these nodules in asymptomatic patients with benign cytology.