2014/06/01 by Payam Farahbakhsh Farsi, Abolghassem Djazayery, Mohammad Reza Eshraghian +6
Medicine · Nursing · #Fatty Acid Research and Health #Liver Disease Diagnosis and Treatment #Nutritional Studies and Diet
paper · pdf · doi:10.1590/0004-2730000002861
crossref issued 2014/06/01 · crossref published 2014/06/01 · crossref published-print 2014/06/01 · openalex publication_date 2014/06/01 · crossref created 2014/06/17 · crossref deposited 2019/08/11 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/02 · crossref indexed 2026/08/02
OBJECTIVE: The aim of this study was to determine the role of omega-3 supplementation on NEFA concentration, insulin sensitivity and resistance, and glucose and lipid metabolism in type 2 diabetic patients. SUBJECTS AND METHODS: Forty-four type 2 diabetic patients were randomly recruited into two groups. Group A received 4 g/day omega-3 soft gels, and group B received a placebo for 10 wks. Blood samples were collected after 12-h fast. Physical activity records, three-day food records, and anthropometric measurements were obtained from all participants at the beginning and end of the study. RESULTS: Omega-3 supplementation caused a significant reduction in NEFA in the intervention group compared with the placebo group (P = 0.009). Additionally, the administration of omega-3 resulted in significantly greater changes (Diff) for the intervention group in various parameters, such as insulin and Quicki indices compared with the placebo group (P < 0.05). CONCLUSIONS: Omega-3 fatty acid supplementation in type 2 diabetic patients improved insulin sensitivity, probably due to the decrease in NEFA concentrations.