Targeting DNA damage in ageing: towards supercharging DNA repair

2025/06/12 by Arturo Bujarrabal-Dueso, George A. Garinis, Paul D. Robbins +2 · 1 voice
Biochemistry, Genetics and Molecular Biology · Medicine · #Autophagy in Disease and Therapy #DNA Repair Mechanisms #RNA Interference and Gene Delivery

paper · doi:10.1038/s41573-025-01212-6

crossref issued 2025/06/12 · crossref published 2025/06/12 · crossref published-online 2025/06/12 · openalex publication_date 2025/06/12 · crossref created 2025/06/12 · crossref deposited 2025/09/30 · crossref published-print 2025/10/01 · openalex created_date 2025/10/10 · crossref indexed 2026/06/05 · openalex updated_date 2026/08/01

Citations

• The serial cultivation of human diploid cell strains
• Pleiotropy, Natural Selection, and the Evolution of Senescence
• The cGAS–STING pathway as a therapeutic target in inflammatory diseases
• A phase 2, randomized, double-blind, placebo-controlled study of senolytic molecule UBX0101 in the treatment of painful knee osteoarthritis
• Multi-omic rejuvenation of human cells by maturation phase transient reprogramming
• cGAS–STING drives ageing-related inflammation and neurodegeneration
• Senolytic therapy in mild Alzheimer’s disease: a phase 1 feasibility trial
• Aging clocks based on accumulating stochastic variation
• Riforma del processo di cassazione e procedente giudiciale: riflessioni nella prospettiva della comparazione "civil law-common law"
• Multi-omics landscape and molecular basis of radiation tolerance in a tardigrade

Discussions

• Bujarrabal-Dueso, A., Garinis, G.A., Robbins, P.D. et al. Targeting DNA damage in ageing: towards supercharging DNA repair. Nat Rev Drug Discov (2025). doi.org/10.1038/s415... [bsky, 0 points, 0 comments]