Mechanistic insights into the ATP-mediated and species-dependent inhibition of TrpRS by chuangxinmycin

2025/01/01 by Yichen Ren, Sili Wang, Wen Liu +2 · 1 voice
Biochemistry, Genetics and Molecular Biology · #ATP Synthase and ATPases Research #Chemical Synthesis and Analysis #Electron Spin Resonance Studies

paper · pdf · doi:10.1039/d5cb00060b

openalex publication_date 2025/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/25

Abstract

TrpRS. These findings deepen our understanding of the inhibitory mechanism of CXM and its selectivity toward bacterial TrpRSs, and thus can facilitate the design of next-generation antibiotics targeting bacterial TrpRSs.

Discussions

• Zoom in on CXM 🔬 New #RSCChemBio study reveals how chuangxinmycin hits bacterial TrpRS enzymes—but not human ones. 10 crystal structures + MD sims = a blueprint for selective antibiotic design. #RS [bsky, 0 points, 0 comments]

Related

• Inhibitors of RecA activity discovered by high-throughput screening: cell-permeable small molecules attenuate the SOS response in Escherichia coli.
• Synergy of ATP and Meropenem in Stimulating the TCA Cycle to Enhance Killing of Carbapenem‐Resistant Acinetobacter baumannii
• Genome‐wide screen reveals a universal role of ATP in ciprofloxacin tolerance among genetically distinct Escherichia coli persisters
• Beyond ATP Synthase Inhibition: Chemical Diversification, Bioactivities, and Therapeutic Potential of Oligomycin A
• Novel Inhibitors of E. coli RecA ATPase Activity.