Electrochemically assisted deprotection of acetals, ketals, and dithioacetals under neutral conditions

2025/01/01 by Yuka Abe, Tsuyoshi Yamada, Takuhei Yamamoto +3 · 1 voice
Chemistry · Environmental Science · #Chemical Synthesis and Reactions #Inorganic and Organometallic Chemistry #Chemical Synthesis and Characterization

paper · doi:10.1039/d4gc06348a

openalex publication_date 2025/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/11

Abstract

A novel electrochemical deprotection method for acetals, ketals and dithioacetals was developed, yielding carbonyl compounds. LiClO 4 acts as both an electrolyte and oxygen source, while 1,3,5-trioxane enhances reaction efficiency as a Li activator.

Citations

• Is electrosynthesis always green and advantageous compared to traditional methods?
• Electro-organic synthesis – a 21 st century technique
• Powering the Future: How Can Electrochemistry Make a Difference in Organic Synthesis?
• Organic Electrochemistry: Molecular Syntheses with Potential
• Electrochemical reactor dictates site selectivity in N-heteroarene carboxylations

Discussions

• 𝐄𝐥𝐞𝐜𝐭𝐫𝐨𝐜𝐡𝐞𝐦𝐢𝐜𝐚𝐥𝐥𝐲 𝐚𝐬𝐬𝐢𝐬𝐭𝐞𝐝 𝐝𝐞𝐩𝐫𝐨𝐭𝐞𝐜𝐭𝐢𝐨𝐧 𝐨𝐟 𝐚𝐜𝐞𝐭𝐚𝐥𝐬, 𝐤𝐞𝐭𝐚𝐥𝐬, 𝐚𝐧𝐝 𝐝𝐢𝐭𝐡𝐢𝐨𝐚𝐜𝐞𝐭𝐚𝐥𝐬 𝐮𝐧𝐝𝐞𝐫 𝐧𝐞𝐮𝐭𝐫𝐚𝐥 𝐜𝐨𝐧𝐝𝐢𝐭𝐢𝐨𝐧𝐬 🔗 doi [bsky, 0 points, 1 comments]