Furosemide, an Old Friend of Nephrologists for the Treatment of CKD: Time to Rethink the Relationship?

2025/05/17 by Jean‐Philippe Bertocchio · 1 voice
Medicine · #Blood Pressure and Hypertension Studies #Heart Failure Treatment and Management #Potassium and Related Disorders

paper · pdf · doi:10.1016/j.ekir.2025.05.021

openalex publication_date 2025/05/17 · openalex created_date 2025/05/18 · openalex updated_date 2026/07/29

Abstract

With more than 18,000 publications referenced in PubMed as of today (including over 4,000 ones with ‘furosemide’ within their title, assuming that they specifically focus on it), furosemide is by far the blockbuster for publishing about diuretics. It has experienced a continuous rise from 1964 (which saw the very first article on this topic1) to 1986 (reaching a peak of almost 500 papers published in a single year), then a decline until 2004 when a new ‘hype’ just began with 2024 almost reaching its historical peak.

Citations

• Furosemide and Serum Protein-Bound Uremic Toxin Concentrations in Patients With CKD

Discussions

• 💧Furosemide, the nephrologist’s old ally, shows benefits in chronic kidney disease: it helps control hypertension and fluid overload, though it may increase uremic toxins. Time to rethink its role in [bsky, 0 points, 0 comments]