Randomized, Placebo-Controlled, Double-Blind, Parallel Design Trial of the Efficacy and Safety of Zestra® in Women With Mixed Desire/Interest/Arousal/Orgasm Disorders

2010/01/04 by David M. Ferguson, Balakrishna Hosmane, Julia R. Heiman · 1 citation
Medicine · Psychology · Social Sciences · #Marriage and Sexual Relationships #Sexual function and dysfunction studies #Sexuality, Behavior, and Technology

paper · doi:10.1080/00926230903375701

openalex publication_date 2010/01/04 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29

Abstract

Over 256 women, age 21 to 65, with acquired mixed female sexual disorders participated in a 16-week randomized, placebo-controlled, double-blind study of Zestra, a topical botanical preparation. Routine outcome instruments measured efficacy and safety. Zestra was well tolerated. The only significant safety finding was mild-to-moderate genital burning seen only in Zestra-treated subjects (14.6%). Zestra provided significant desire, arousal, and treatment satisfaction benefits for a broadly generalized group of women with sexual difficulties.

Citations

• Comparison of Beck Depression Inventories-IA and-II in Psychiatric Outpatients
• Measuring Dyadic Adjustment: New Scales for Assessing the Quality of Marriage and Similar Dyads
• The Female Sexual Function Index (FSFI): A Multidimensional Self-Report Instrument for the Assessment of Female Sexual Function
• Randomized, Placebo-Controlled, Double Blind, Crossover Design Trial of the Efficacy and Safety of Zestra for Women in Women With and Without Female Sexual Arousal Disorder

Cited by

• Zestra [wikipedia]