Mycothiol: synthesis, biosynthesis and biological functions of the major low molecular weight thiol in actinomycetes

2008/01/01 by Vishnu Karthik Jothivasan, Chris J. Hamilton · 5 citations
Biochemistry, Genetics and Molecular Biology · #Glutathione Transferases and Polymorphisms #Polyamine Metabolism and Applications #Redox biology and oxidative stress

paper · doi:10.1039/b616489g

openalex publication_date 2008/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30

Abstract

Actinomycetes produce mycothiol as their major low molecular weight thiol, which parallels the functions of glutathione found in prokaryotes and most Gram-negative bacteria. This review covers progress that has so far been made in terms of its distribution, biosynthesis and metabolic functions, as well as chemical syntheses of mycothiol and alternative substrates and inhibitors of mycothiol biosynthesis and mycothiol-dependent enzymes. 152 references are cited.

Citations

• Glutathione in Bacteria
• A STUDY OF SOME PROPERTIES OF EXCITED STATES IN LIGHT NUCLEI USING HELIUM-3-INDUCED REACTIONS

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• Mycothiol [wikipedia]