2008/02/07 by Yuri Roiter, Maryna Ornatska, Aravind Rammohan +3 · 1 citation
Biochemistry, Genetics and Molecular Biology · Physics and Astronomy · #Force Microscopy Techniques and Applications #Lipid Membrane Structure and Behavior #Spectroscopy and Quantum Chemical Studies
paper · doi:10.1021/nl080080l
openalex publication_date 2008/02/07 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/25
A nanoscale range of surface feature curvatures where lipid membranes lose integrity and form pores has been found experimentally. The pores were experimentally observed in the l-alpha-dimyristoyl phosphatidylcholine membrane around 1.2-22 nm polar nanoparticles deposited on mica surface. Lipid bilayer envelops or closely follows surface features with the curvatures outside of that region. This finding provides essential information for the understanding of nanoparticle-lipid membrane interaction, cytotoxicity, preparation of biomolecular templates and supported lipid membranes on rough and patterned surfaces.