2025/07/21 by Chiara Pozzi, Riccardo Sarti, Antonino Lo Cascio +17 · 1 voice
Medicine · Biochemistry, Genetics and Molecular Biology · #Cancer Cells and Metastasis #Vascular Tumors and Angiosarcomas #Cancer Research and Treatments
paper · doi:10.1038/s44321-025-00277-5
openalex publication_date 2025/07/21 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/23
Identification of biomarkers for the hematogenous spreading of cancer cells is of paramount prognostic and therapeutic value. We showed that Plasmalemma Vesicle Associated Protein-1 (PV-1) serves as a marker of increased blood vessel permeability and is an independent predictor of colorectal cancer dissemination. This study investigates whether PV-1 can also act as a prognostic marker for distant metastases in other solid tumors. We analyzed samples from 134 patients: 30 luminal breast cancer (BC), 52 clear cell renal cell carcinoma (ccRCC), and obtained preliminary data from 52 soft tissue sarcomas (STS). A higher frequency of PV-1+ endothelial cells was significantly associated with metastatic progression in luminal BC and ccRCC. Moreover, the frequency of PV-1+ cells emerged as a significant prognostic factor for metastasis-free survival in both luminal BC and ccRCC. Further research is needed to validate PV-1's prognostic utility, as including it at diagnosis may change the management of these patients and should allow stratification for more aggressive therapies or for closer follow-ups to promptly intervene in case of metastases development.