2025/07/31 by Ursula Søndergaard, Kolle E. Thomas, Rune Sundset +4 · 1 voice · 1 citation
Medicine · #Medical Imaging Techniques and Applications #Medical Imaging and Pathology Studies #Radiopharmaceutical Chemistry and Applications
paper · pdf · doi:10.1007/s10967-025-10270-4
openalex publication_date 2025/07/31 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/03
Abstract Increasing interest in 67 Cu for targeted radionuclide therapy necessitates development of robust and validated analytical methods to ensure compliance with regulatory standards for clinical translation. We validated methods based on inductively coupled plasma optical emission spectroscopy (ICP-OES) and high-purity germanium (HPGe) γ-spectrometry. For ICP-OES, criteria were met for most elements, with Al and Ca, suffering matrix effects. Apparent molar activity calculated by ICP-OES was congruent with DOTA-titration-based effective molar activity when Al and Ca were excluded. HPGe γ-spectrometry was shown to enable accurate discrimination and quantification of co-produced radionuclides ( 67 Ga, 66 Ga, 69m Zn) from 67 Cu at 99.5% radionuclidic purity.