Suspension stability of aluminum-based adjuvants

2025/01/01 by Zhihui Liang, Hongyang Gao, Qian Ren +4 · 1 voice
Engineering · #Aluminum Alloys Composites Properties #Structural Analysis and Optimization #Structural Response to Dynamic Loads

paper · doi:10.1039/d5nr00699f

openalex publication_date 2025/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/22

Abstract

potential, surface free energy (SFE) and hydrophobicity. Notably, the commercial adjuvant Alhydrogel® exhibited low suspension stability compared to our synthesized AlOOH nanoparticles, a result attributed to its high SFE. Furthermore, under specific formulation conditions, aluminum-based adjuvants with enhanced suspension stability improved the suspension stability of their corresponding adjuvant-antigen complexes. This study provides a foundation for optimizing the suspension stability of aluminum-based adjuvants and offers valuable insights for their rational design and transportation in vaccine development.

Citations

• Emerging concepts in the science of vaccine adjuvants

Discussions

• In Nanoscale's inside front cover article, the authors synthesise a series of aluminium hydroxyphosphate and AlOOH nanoparticles and systematically evaluated their suspension stabilities under various [bsky, 0 points, 0 comments]

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