The anorexigenic peptide nesfatin-1 dampens the B cell response to receptor-mediated stimulation through inhibition of NF-κB signaling

2025/03/26 by Tara L. Steffen, Joshua D. Stafford, Colleen Bocke +2 · 1 voice
Medicine · Neuroscience · #Adipokines, Inflammation, and Metabolic Diseases #Regulation of Appetite and Obesity #Adipose Tissue and Metabolism

paper · pdf · doi:10.1152/ajpregu.00233.2024

openalex publication_date 2025/03/26 · openalex created_date 2025/03/27 · openalex updated_date 2026/06/09

Abstract

This study establishes an interaction of nesfatin-1 and a human B cell line, Raji. Nesfatin-1 was shown to limit the B cell response to receptor-mediated stimulation, an action that has potential implications within the immune system and the development of chronic inflammation associated with the obese state. This study, along with previously published works, highlights a need for further research on nesfatin-1's interactions with adipocytes and immune cells.

Citations

• Toll-like Receptors and the Control of Immunity
• Adipose tissue inflammation and metabolic dysfunction in obesity
• IgM-associated gut bacteria in obesity and type 2 diabetes in C57BL/6 mice and humans

Discussions

• @slu-official.bsky.social researchers recently discovered that appetite regulating molecule Nesfatin-1 inhibits B cell activation and growth, identifying a mechanistic link between the molecule and it [bsky, 0 points, 0 comments]