Mycobacterium tuberculosis Dihydrofolate Reductase Reveals Two Conformational States and a Possible Low Affinity Mechanism to Antifolate Drugs

2013/11/07 by M.V.B. Dias, Marcio Vinicius Bertacine Dias, Petros Tyrakis +7 · 1 voice
Biochemistry, Genetics and Molecular Biology · Medicine · #Biochemical and Molecular Research #Pneumocystis jirovecii pneumonia detection and treatment #Tuberculosis Research and Epidemiology

paper · pdf · doi:10.1016/j.str.2013.09.022

openalex publication_date 2013/11/07 · crossref created 2013/11/07 · crossref issued 2014/01/01 · crossref published 2014/01/01 · crossref published-print 2014/01/01 · crossref deposited 2019/08/01 · openalex created_date 2025/10/10 · crossref indexed 2026/06/19 · openalex updated_date 2026/07/28

Citations

• PROCHECK: a program to check the stereochemical quality of protein structures
• The folic acid biosynthesis pathway in bacteria: evaluation of potential for antibacterial drug discovery

Discussions

• While loss of Stat3 didn't seem to do much vs the infection in our models we found Daraprim had an antibiotic effect closing the loop on the binding of Daraprim to mycobacterial DHFR (doi.org/10.1016/ [bsky, 0 points, 1 comments]