2025/08/12 by Sean V. Connelly, Julia G Muller, Mohamed H. Ali +26 · 1 voice
Biochemistry, Genetics and Molecular Biology · Medicine · #Cholesterol and Lipid Metabolism #Malaria Research and Control #Plant biochemistry and biosynthesis
paper · pdf · doi:10.1093/infdis/jiaf431
openalex publication_date 2025/08/12 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
Artemisinin partial resistance, driven by Plasmodium falciparum K13 mutations, threatens malaria control. Zanzibar is vulnerable to artemisinin partial resistance spread but lacks recent molecular surveillance. We sequenced samples in Zanzibar and mainland Tanzania collected from 2022 to 2024. K13 mutations were found in 2 of 1440 participants (P441L, A675V) in Zanzibar and 6 of 3762 (R561H, P441L) in mainland Tanzania. Based on whole genome sequencing data, K13 mutations appear to be of African origin with regional spread. Frequent parasite importation appears to maintain partner drug mutation frequencies similar to the mainland, where artemether-lumefantrine selects for mutations favoring artesunate-amodiaquine sensitivity. Ongoing molecular surveillance remains essential to track these patterns.