2012/01/31 by Chung Sub Kim, Chung Kim, Sang Choi +2 · 1 citation
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · #Biological Activity of Diterpenoids and Biflavonoids #Natural product bioactivities and synthesis #Phytochemistry and Biological Activities
paper · doi:10.1055/s-0031-1298215
crossref issued 2012/01/31 · crossref published 2012/01/31 · crossref published-online 2012/01/31 · openalex publication_date 2012/01/31 · crossref created 2012/02/01 · crossref published-print 2012/03/01 · openalex created_date 2016/06/24 · crossref deposited 2017/05/22 · openalex updated_date 2026/08/01 · crossref indexed 2026/08/01
Three new diterpenoids, 18-formyloxy-8 β-hydroxysandaracopimar-15-ene (1), 15(R)-N-butoxypinusolidic acid (2), and 15,16-dihydro-15,16-dimethoxylambertianic acid (3), along with twelve known compounds (4-15) were isolated from MeOH extracts of leaves of Thuja orientalis L. The structures of the three new compounds were elucidated on the basis of spectroscopic analyses, including extensive 2D-NMR data. The absolute stereochemistry of compound 2 was clarified by a CD spectroscopic study. The isolated compounds were evaluated for cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines in vitro using the sulforhodamin B (SRB) bioassay.