1985/12/01 by Hermann Ammon, H. P. T. Ammon, Axel Müller · 1 citation
Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #Medicinal Plants and Bioactive Compounds #Pharmacological Effects of Natural Compounds #Plant-based Medicinal Research
paper · pdf · doi:10.1055/s-2007-969566
crossref issued 1985/12/01 · crossref published 1985/12/01 · crossref published-print 1985/12/01 · openalex publication_date 1985/12/01 · crossref published-online 2007/02/26 · crossref created 2007/03/07 · openalex created_date 2016/06/24 · crossref deposited 2017/05/23 · openalex updated_date 2026/08/01 · crossref indexed 2026/08/01
Ancient Hindu Ayurvedic texts described the use of extracts from COLEUS species. An isolated diterpene from COLEUS FORSKOHLII, called forskolin, was demonstrated to be a hypotensive agent with spasmolytic, cardiotonic and platelet aggregation inhibitory activity. It has been shown to be a powerful activator of the enzyme adenylate cyclase in various tissues. Forskolin is thought to act on the catalytic subunit and also on the coupling mechanism of guanine regulatory sites (Ns and Ni) with the catalytic subunit. It is now clear that forskolin elicits physiological responses which have been shown to be cAMP-dependent.