2018/11/27 by Yun Song, Giorgos C. Karakousis
Medicine · #CAR-T cell therapy research #Cutaneous Melanoma Detection and Management #Nonmelanoma Skin Cancer Studies
paper · doi:10.1002/jso.25302
crossref issued 2018/11/27 · crossref published 2018/11/27 · crossref published-online 2018/11/27 · openalex publication_date 2018/11/27 · crossref created 2018/11/27 · crossref published-print 2019/01/01 · crossref deposited 2023/09/10 · openalex created_date 2025/10/10 · crossref indexed 2026/08/01 · openalex updated_date 2026/08/01
Formally described in the 1960s, melanoma of unknown primary (MUP) is characterized by the finding of metastatic melanoma within the lymph nodes, subcutaneous tissues, and other distant sites without an evident primary lesion. The most likely hypothesis of its etiology is an immune-mediated regression of the primary after metastasis has occurred. In addition, patients with MUP appear to have equivalent or better outcomes compared with patients with known primaries of a similar stage.