2025/08/19 by M. E. Trejo-Caballero, Alberto Elizalde-Mata, Marlén Alexis González-Reyna +5 · 1 voice
Biochemistry, Genetics and Molecular Biology · Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Traditional and Medicinal Uses of Annonaceae #Carbohydrate Chemistry and Synthesis #Alkaloids: synthesis and pharmacology
paper · doi:10.1016/j.cej.2025.167354
openalex publication_date 2025/08/19 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/15
This study investigates the development of an alginate-based natural composite incorporating antioxidant and antimicrobial acetogenins from Annona cherimola Mill., synthesized via free-radical polymerization using deep eutectic solvent (DES) and a natural deep eutectic solvent (NADES) system. The composite demonstrates pH and thermo-responsive properties for controlled and prolonged release of acetogenins. The antioxidant capacity, sorption behavior, and release profiles are evaluated through spectroscopic and electrochemical analyses. The antibacterial activity is examined, which can disrupt bacterial integrity, induce oxidative stress through reactive oxygen species (ROS), and damage bacterial DNA. The composite (MC-PA) exhibits antibacterial efficacy exceeding 90 % against Pseudomonas aeruginosa and Staphylococcus aureus . It also shows promising activity against antibiotic-resistant strains after 30 min of exposure, with a release of ACGs less than 250 μg. These findings highlight the potential of the MC-PA composite for use as innovative biomaterials in sustained acetogenin delivery systems and therapeutic antibacterial applications.