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Role of Magnesium in Vitamin D Activation and Function

2018/02/26 by Anne Marie Uwitonze, Mohammed S. Razzaque · 1 voice · 4 citations
Health Professions · Medicine · Nursing · #Intestinal and Peritoneal Adhesions #Magnesium in Health and Disease #Therapeutic Uses of Natural Elements

paper · doi:10.7556/jaoa.2018.037

openalex publication_date 2018/02/26 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/03

Abstract

Nutrients usually act in a coordinated manner in the body. Intestinal absorption and subsequent metabolism of a particular nutrient, to a certain extent, is dependent on the availability of other nutrients. Magnesium and vitamin D are 2 essential nutrients that are necessary for the physiologic functions of various organs. Magnesium assists in the activation of vitamin D, which helps regulate calcium and phosphate homeostasis to influence the growth and maintenance of bones. All of the enzymes that metabolize vitamin D seem to require magnesium, which acts as a cofactor in the enzymatic reactions in the liver and kidneys. Deficiency in either of these nutrients is reported to be associated with various disorders, such as skeletal deformities, cardiovascular diseases, and metabolic syndrome. It is therefore essential to ensure that the recommended amount of magnesium is consumed to obtain the optimal benefits of vitamin D.

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