2025/09/13 by Dénes Türei, Jonathan Schaul, Nicolàs Palacio‐Escat +29 · 1 voice
Biochemistry, Genetics and Molecular Biology · #Bioinformatics and Genomic Networks
paper · pdf · doi:10.1101/2025.09.11.675512
openalex publication_date 2025/09/13 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/22
Abstract Analysis and interpretation of omics data largely benefit from the use of prior knowledge. However, this knowledge is fragmented across resources and often is not directly accessible for analytical methods. We developed OmniPath ( https://omnipathdb.org/ ), a database combining diverse molecular knowledge from 168 resources. It covers causal protein-protein, gene regulatory, miRNA, and enzyme-PTM (post-translational modification) interactions, cell-cell communication, protein complexes, and information about the function, localization, structure, and many other aspects of biomolecules. It prioritizes literature curated data, and complements it with predictions and large scale databases. To enable interactive browsing of this large corpus of knowledge, we developed OmniPath Explorer, which also includes a large language model (LLM) agent that has direct access to the database. Python and R/Bioconductor client packages and a Cytoscape plugin create easy access to customized prior knowledge for omics analysis environments, such as scverse. OmniPath can be broadly used for the analysis of bulk, single-cell and spatial multi-omics data, especially for mechanistic and causal modeling. Graphical Abstract