2025/11/25 by Xiaosu Miao, Guang Hu · 1 voice
Biochemistry, Genetics and Molecular Biology · Neuroscience · #RNA Research and Splicing #Neurogenesis and neuroplasticity mechanisms #Wnt/β-catenin signaling in development and cancer
paper · pdf · doi:10.1186/s13619-025-00250-0
openalex publication_date 2025/11/25 · openalex created_date 2025/11/25 · openalex updated_date 2026/06/13
Eukaryotic mRNAs are polyadenylated at their 3'-ends, and the poly(A) tails play critical roles in post-transcriptional gene regulation by influencing mRNA stability and translation. Here, we describe the biological processes and major protein factors that control poly(A) tail synthesis and shortening. We also discuss recent breakthroughs in poly(A) tail sequencing methods that enable high throughput and accurate measurement of poly(A) tail lengths. Finally, we review how poly(A)-tail regulators and poly(A)-tail-mediated post-transcriptional mechanisms affect stem cell fate and early embryonic development.