The importance of sex differences in valvular heart disease from an imaging point of view

2025/11/08 by Paolo Springhetti, Ana G. Almeida, Denisa Muraru +1 · 1 voice
Medicine · Biochemistry, Genetics and Molecular Biology · #Cardiac Valve Diseases and Treatments #Cardiovascular Function and Risk Factors #Congenital heart defects research

paper · doi:10.1093/ehjci/jeaf311

openalex publication_date 2025/11/08 · openalex created_date 2025/11/13 · openalex updated_date 2026/07/28

Abstract

Sex differences in valvular heart disease (VHD) represent an emerging focus in cardiovascular imaging, with implications spanning aetiology, pathophysiology, chamber remodelling, and prognosis. This review aims to illustrate how multimodality imaging can be applied to address sex-specific differences in VHD, with the goal of improving disease grading, staging of extra-valvular cardiac damage, and risk stratification across the whole VHD spectrum.

Citations

• Atrial secondary tricuspid regurgitation: pathophysiology, definition, diagnosis, and treatment
• A novel staging system of cardiac damage in aortic stenosis based on multi-chamber myocardial deformation

Discussions

• #EHJCVI 🩺 A new review shows how sex differences influence every stage of valvular heart disease, from aetiology to imaging features and timing of intervention 📊 Multimodality imaging is key to prev [bsky, 0 points, 0 comments]