Hematopoietic stem cell transplantation for extracranial germ cell tumors

2025/11/26 by Neysimelia Costa Villela, Patricia Shimoda Ikeuti, Paulo Henrique dos Santos Klinger +3 · 1 voice
Medicine · #Acute Myeloid Leukemia Research #Glioma Diagnosis and Treatment #Testicular diseases and treatments

paper · pdf · doi:10.46765/2675-374x.2025v6n1e291

openalex publication_date 2025/11/26 · openalex created_date 2025/11/27 · openalex updated_date 2026/06/11

Abstract

Malignant extracranial germ cell tumors (GCT) are uncommon in the pediatric population. Most affected children can achieve cure using conventional chemotherapy combined with appropriate local control. The role of high-dose chemotherapy with autologous stem cell transplantation (HDCT/ASCT) in GCT has been studied mainly in adult cohorts. In this article, we reviewed the current evidence and indications for HDCT/ASCT in the management of pediatric GCT.

Citations

• Role of one, two and three doses of high-dose chemotherapy with autologous transplantation in the treatment of high-risk or relapsed testicular cancer: a systematic review

Discussions

• Children who reached complete or partial remission before HDCT/ASCT showed a 5-year overall survival of 62.5%, while those with progressive disease had 0% event-free survival. Pre-transplant response [bsky, 0 points, 0 comments]